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KMID : 0363219770150040437
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Korean Journal of Dermatology
1977 Volume.15 No. 4 p.437 ~ p.441
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A Clinical Study on the Therapeutic Effect of Clocortolone on some Dermatoses
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崔鍾聲/Choi, Jong Sung
金光中/朴暲圭/金源錫/李惟信/Kim, Kwang Joong/Park, Jang Kyu/Kim, Won Suk/Lee, Yoo Shin
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Abstract
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Clocortolone (9-α-chloro-6-α fluoro-1 l-β 21 dihydroxy-16 methyl pregnal, 4-diene) is a newly synthesized corticosteroid which has been found to have potent antiinfjammatory action and good tolerance through animal experiment. Several investigators reported its therapeutic effect in various dermatoses by topical application.
The present study was undertaken to evaluate the therapeutic effect of 0. 1 % clocortolone cream (Purantix-Sandoz) in patients with eczematous dermatoses and with psoriasis and to compare its effect with that of 1 % hydrocortisone. Eleven patients with contact dermatitis, 10 with atopic dermatitis, 10 with neurodermatitis, ~6 with nummular eczema and 10 with psoriasis entered this study during the period of 6 months from January to June, 1977 at the Department of Dermatology, Seoul National University Hospital. All patients were instructed tc apply 0. 1 % Clocortolone cream on one side of their lesion and 1 % hydrocortisone cream on the opposite site for two weeks.
After two weeks´ period of observation the status of the lesion was evaluated clinically and the results were as follows.
1. Ninety one percent of patients with contact dermatitis, 70 % of atopic dermatitis, 60 % of neurodermatitis, 67 to of nummular eczema and 60 % of psoriasis responded very effectively or moderately effectively. The therapeutic responses were generally similar to that of 1% hydrocortisone.
2. During the observation period, there was no systemic or local side effect of 0. 1 % Clocortolone cream.
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